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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.25 mg/kg or 0.1 mg/kg. "The findings are consistent with our hypothesis that prolonged administration of prednisolone has an effect on steroidogenesis through suppression of the P450 2D6 enzyme system, thereby stimulating progesterone production," Dr. Tzavary said. In a separate study recently published in The Journal of Steroid Biochemistry and Molecular Biology, Dr. Vidal-Moyo and his colleagues show that the steroidogenic hormone dehydroepiandrosterone (DHEA) can be directly targeted by an inhibitor of the P450 2D6 enzyme system. DHEA stimulates progesterone synthesis through the interaction of the steroidogenic hormone with the enzyme. While there are a number of inhibitors of P450 2D6 and other metabolic enzymes that may be applicable in the prevention of pregnancy or for other therapeutic purposes, this particular inhibitor represents the first such inhibitor used to inhibit the effects of dendritic cell proliferation in a study of human pregnancy, which raises the possibility that it was an effective therapeutic agent when used before any adverse effects of pregnancy development were apparent. "Our study shows that dendritic cell proliferation is directly involved in the response of progesterone production to the steroid steroid, and that this effect is mediated by the reduction in P450 2D6 inhibition by the inhibitor," Dr. Tzavary said. The findings open the door for future research and development into the treatment of various conditions related to pregnancy. "To address this question of why, on the one hand, pregnant women develop benign pregnancies in response to the use of the drug progesterone during pregnancy, and on the other hand, pregnant women don't develop malformations in response to the use of the drug during pregnancy," Dr. Tzavary said. ### UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with nationally renowned programs in basic, biomedical, translational and population sciences; and a preeminent biomedical research enterprise. It includes hospitals, UCSF Medical Center and UCSF Benioff Children's Hospitals San Francisco, and other partner and affiliated hospitals and healthcare providers throughout the Bay Area. Related Article: